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Fully sequenced samples of complimentary DNA synthesized from single-stranded, mammalian RNA. Various gene inserts sourced from humans, mice, monkeys, and other species are available. Ideal for use in gene cloning, as gene probes, and in cDNA library creation.
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Predicted to be involved in endoplasmic reticulum organization and regulation of intracellular transport. Located in endoplasmic reticulum tubular network.
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This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
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Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) also known as CD134 and OX40 receptor OX40 is a secondary co-stimulatory immune checkpoint molecule expressed after 24 to 72 hours following activation its ligand OX40L is also not expressed on resting antigen presenting cells but is following their activation
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DNAM-1 (DNAX accessory molecule-1) also known as CD226 platelet and T cell activation antigen 1 (PTA1) and TLiSA1 is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22 3 DNAM-1 is an activating receptor expressed on natural killer (NK) cells CD8 T cells and other immune cells Upon recognition of its ligands CD155 and CD112 DNAM-1 promotes NK cell mediated elimination of transformed and virus-infected cells It also has a key role in expansion and maintenance of virus-specific memory NK cells DNAM-1 is the cell surface receptor of NECTIN2 Upon ligand binding it stimulates T cell proliferation and cytokine production including that of IL2 IL5 IL10 IL13 and IFNG
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